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Citation
Tags
HERO ID
3420229
Reference Type
Journal Article
Title
Association of GSTT1 gene polymorphisms with the risk of prostate cancer: an updating meta-analysis
Author(s)
Wang, J; Xu, Y; Fu, Q; Yu, J; Chen, Z; Liu, Z; Li, C; Guo, Hui; Xie, M
Year
2013
Is Peer Reviewed?
1
Journal
Tumor Biology
ISSN:
1010-4283
EISSN:
1423-0380
Volume
34
Issue
3
Page Numbers
1431-1440
Language
English
PMID
23456766
DOI
10.1007/s13277-012-0640-8
Web of Science Id
WOS:000319356900014
Relationship(s)
has retraction
4098513
Retraction Note to multiple articles in Tumor Biology
Abstract
It has been demonstrated that the glutathione S-transferase (GST) superfamily helps remove carcinogens from the body and thus might be associated with prostate cancer risk. In recent years, GSTT1 polymorphism has been extensively studied as a potential prostate cancer risk factor; however, the results are inconsistent. To investigate the association between GSTT1 and prostate cancer, we conducted a meta-analysis of 33 studies with 6,697 prostate patients and 7,643 controls. For GSTM1 null versus present genotype, the random effects odds ratio was 0.98 (95 % confidence interval (CI) 0.83-1.16) based on a wide population. Subgroup analyses in the different ethnic groups and different controls were performed. The OR was 1.01 (95 % CI 0.86-1.19) in Caucasians, 1.01 (95 % CI 0.70-1.47) in Asians, and 0.77 (95 % CI 0.42-1.42) in Africans. The OR was 0.98 (95 % CI 0.82-1.16) in non-benign prostate hyperplasia (BPH) controls and 1.09 (95 % CI 0.66-1.79) in BPH controls. In conclusion, our present meta-analysis demonstrates that there is no association between GSTT1 polymorphism and prostate cancer, even in the sub-analysis concerning different races and control sources. The direction of further research should focus not only on the simple relationship of GSTT1 and prostate cancer but also on gene-environment interaction and distinctions of different GSTs.
Keywords
Prostate cancer; Susceptibility; Glutathione transferase; GSTT1; Genetic polymorphism
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