Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3434566
Reference Type
Journal Article
Title
Aberrant DNA methylation in the pathogenesis of atherosclerosis
Author(s)
Hai, Z; Zuo, W
Year
2016
Is Peer Reviewed?
Yes
Journal
Clinica Chimica Acta
ISSN:
0009-8981
EISSN:
1873-3492
Volume
456
Page Numbers
69-74
Language
English
PMID
26944567
DOI
10.1016/j.cca.2016.02.026
Web of Science Id
WOS:000375357900013
URL
https://linkinghub.elsevier.com/retrieve/pii/S0009898116300717
Exit
Abstract
Atherosclerosis, a multifactorial disease of large- and intermediate-sized arteries, is characterized by the accumulation of lipids and the proliferation of arterial smooth muscle cells, chronic inflammatory cells, and fibrous materials. DNA methylation involves inherent and acquired gene transcription changes, which occur independently of the DNA sequence. DNA methylation in the genome plays a major role in the development and progression of atherosclerosis. DNA methylation is a distinct and crucial mechanism that regulates genes governing cell proliferation, thereby linking environmental insults with gene regulation. DNA methyltransferases are crucial in maintaining endothelial cell integrity, promoting smooth muscle cell proliferation, and inducing the formation of arteriosclerosis in animal models. These enzymes, which influence DNA methylation in vascular cells, may be utilized to develop new diagnoses and treatments for atherosclerosis-related diseases. In this review, we focus on recent advances in the description and functional interpretation of the DNA methylome of cells and tissues involved in atherosclerosis. We also discuss the regulatory mechanism and the involvement of DNA methylation in the development and pathogenesis of atherosclerosis. (C) 2016 Elsevier B.V. All rights reserved.
Keywords
Atherosclerosis; DNA methylation; Oxidative stress; Inflammation
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity