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HERO ID
3444883
Reference Type
Book/Book Chapter
Title
Developmental and reproductive disorders: Role of endocrine disruptors in testicular toxicity
Author(s)
Rezk, BM; Sikka, S
Year
2011
Is Peer Reviewed?
Yes
Publisher
Academic Press
Location
San Diego, CA
Book Title
Reproductive and developmental toxicology
Page Numbers
903–912
Language
English
DOI
10.1016/B978-0-12-382032-7.10069-4
Web of Science Id
WOS:000318575300070
Relationship(s)
is a chapter of
2849992
Reproductive and developmental toxicology
has other version or edition
4779370
Developmental and reproductive disorders: Role of endocrine disruptors in testicular toxicity
Abstract
This chapter describes how a variety of extraneous and internal factors can induce developmental and testicular toxicity leading to teratogenesis, poor sperm quality and male factor infertility. Developmental and reproductive toxicologists and epidemiologists have identified and classified several environmental chemicals and pharmaceutical products including teratogens and endocrine disruptors that lead to developmental and reproductive disorders. Hence, it is extremely important to understand the role of such toxicants and environmental endocrine disruptors. Convincing evidence exists that chemical exposures may lead to increased estrogenic activity, reduced androgen levels, or otherwise interfere with the action of androgen during development, thus causing male reproductive system abnormalities. The severity of testicular damage is related to the category of chemotherapeutic agent used, the dose and duration of therapy, and the developmental stage of the testis. The recovery of spermatogenesis is variable and depends upon the total therapeutic dose and duration of treatment. In addition to endocrine-disruptor mechanisms, endocrine disruptors including pesticides, xenobiotics, heavy metals, radiations, smoking and alcohol generate free radicals that can induce developmental and reproductive abnormalities. Reactive oxygen species (ROS) can also induce oxidation of critical-SH groups in proteins and DNA, which will alter cellular integrity and function with an increased susceptibility to attack by toxicants. The hazard identification and dose–response data are developed from experimental animal studies that may be supplemented with data from in vitro studies. This information is then extrapolated and integrated to characterize and assess the risk to the human population.
Keywords
Endocrine disruptors; Environmental toxicants; Male reproduction; Testicular toxicity; Testis development
Editor(s)
Gupta, RC
ISBN
9780123820327
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Additional Strategies
March 2017 Search strategy results
Secondary Literature
Reviews and Editorials
PFAS
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PFDA
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