Health & Environmental Research Online (HERO)


Print Feedback Export to File
3447394 
Journal Article 
Review 
The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition 
Elsherbiny, ME; Brocks, DR 
2011 
Yes 
Drug Metabolism Reviews
ISSN: 0360-2532
EISSN: 1097-9883 
43 
4 
457-475 
English 
21823901 
As part of everyday life, people are exposed to polycyclic aromatic hydrocarbons (PAHs). Sources of PAHs include cigarette smoke, ingestion of contaminated food and water or specifically charcoal-grilled meat, and occupational exposure (e.g., the coal industry). PAH compounds are well known to have enzyme-inducing effects, especially on the cytochrome P450 (CYP) family of enzymes, including CYP1A. Enhanced clearance of CYP1A-metabolized drugs as a result of PAH exposure is well established. However, there are examples where PAH-containing sources enhanced the clearance or altered the disposition of some non-CYP1A-metabolized drugs. It has been shown that not only do these compounds induce CYP1A isoforms, but they also can alter the expression of other CYPs, such as 1B1/2 and 2E1, certain phase II enzymes, some transport proteins (in animal models and cell lines), levels of plasma proteins (e.g., α1-acid glycoprotein and lipoproteins), and liver mass. Changes in any of these parameters can lead to changes in the biological disposition of a wide variety of drugs by altering either their concentrations in blood or tissues. Identification of patients with elevated enzyme activities or otherwise altered physiological parameters as a consequence of exposure to PAH could serve to lessen the risks and optimize therapeutic benefits of drug therapy. In this article, the pharmacokinetic properties of PAH, the possible mechanisms by which they can alter drug disposition, and specific examples are discussed. 
Charcoal broiled; CYP1A; Drug metabolism; Enzyme induction; Pharmacokinetics; Polycyclic aromatic hydrocarbons; Tobacco smoke