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3481156 
Journal Article 
Protective effects of Sonchus asper (L.) Hill, (Asteraceae) against CCl(4-)induced oxidative stress in the thyroid tissue of rats 
Khan, RA 
2012 
Yes 
BMC Complementary and Alternative Medicine
ISSN: 1472-6882
EISSN: 14726882 
12 
181 
English 
23043630 
BACKGROUND: Sonchus asper (L.) Hill, (Asteraceae) is used in Pakistan as a traditional ("folk") medicine for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Sonchus asper (L.) Hill, (Asteraceae) methanolic extract (SAME) on hormonal dysfunction in thyroid tissue after carbon tetrachloride (CCl4)-induced oxidative stress.

METHODS: To examine the effects of SAME against the oxidative stress of CCl4 in thyroid tissue, 30 male albino rats were used. Protective effects of SAME were observed on thyroid hormonal levels, activities of antioxidant enzymes, lipid peroxidation (TBARS) and DNA damage.

RESULTS: Treatment with CCl4 significantly (P<0.01) reduced the levels of T3 and T4 and increased TSH levels. CCl4 exposure in rats reduced the activities of antioxidant enzymes but increased lipid peroxidation and DNA damage. Co-administration of SAME significantly (P<0.01) improved these alterations with respect to hormonal levels, activities of antioxidant enzymes and lipid peroxidation close to those seen in control rats.

CONCLUSION: These results suggest that SAME can protect thyroid tissue against oxidative damage, possibly through the antioxidant effects of its bioactive compounds. 
Alternative Medicine; Plant Extracts; Protective Agents; Thyroid Hormones; Carbon Tetrachloride; Catalase; Peroxidase; Superoxide Dismutase; NAD(P)H Dehydrogenase (Quinone); Thyroid gland; Rodents; Hormones; Antioxidants; Enzymes; Proteins; Pakistan; Thyroid Gland -- enzymology; Carbon Tetrachloride -- adverse effects; Thyroid Hormones -- blood; Catalase -- metabolism; Lipid Peroxidation -- drug effects; DNA Damage -- drug effects; Animals; Thyroid Gland -- drug effects; Peroxidase -- metabolism; Superoxide Dismutase -- metabolism; NAD(P)H Dehydrogenase (Quinone) -- metabolism; Plant Extracts -- administration & dosage; Protective Agents -- administration & dosage; Oxidative Stress -- drug effects; Thyroid Gland -- metabolism; Sonchus -- chemistry