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Citation
Tags
HERO ID
3483282
Reference Type
Journal Article
Subtype
Review
Title
The cave microbiome as a source for drug discovery: Reality or pipe dream?
Author(s)
Ghosh, S; Kuisiene, N; Cheeptham, N
Year
2017
Is Peer Reviewed?
Yes
Journal
Biochemical Pharmacology
ISSN:
0006-2952
EISSN:
1873-2968
Volume
134
Page Numbers
18-34
Language
English
PMID
27867014
DOI
10.1016/j.bcp.2016.11.018
Abstract
This review highlights cave habitats, cave microbiomes and their potential for drug discovery. Such studies face many challenges, including access to remote and pristine caves, and sample collection and transport. Inappropriate physical and chemical growth conditions in the laboratory for the isolation and cultivation of cave microorganisms pose many complications including length of cultivation; some cave microorganisms can take weeks and even months to grow. Additionally, DNA extraction from cave environmental samples may be difficult due to the high concentration of various minerals that are natural DNA blocking agents. Once cave microorganisms are grown in the lab, other problems often arise, such as maintenance of pure culture, consistency of antimicrobial activity and fermentation conditions for antimicrobial production. In this review, we suggest that, although based on what has been done in the field, there is potential in using cave microorganisms to produce antimicrobial agents, one needs to be highly committed and prepared.
Tags
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jul 2016 - Jan 2017
Considered new
PubMed
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
January 2017 Update
July 2017 Update
PubMed
No Primary Data on Toxic Effects
Not chemical specific
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
Excluded
Source - August 2017 Update (Private)
Pubmed
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