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3579145 
Journal Article 
Thermodynamic analysis and correlation of solubility of candesartan cilexetil in aqueous solvent mixtures 
Cui, P; Yin, Q; Gong, J; Wang, Y; Hao, H; Xie, C; Bao, Y; Zhang, M; Hou, B; Wang, J 
2013 
Yes 
Fluid Phase Equilibria
ISSN: 0378-3812 
337 
354-362 
WOS:000315325500039 
The solubility of candesartan cilexetil (Form I) was measured by a gravimetric method in aqueous solvent mixtures (ethanol-water, acetonitrile-water and acetone-water), and the calculated values by (NIBS)/Redlich-Kister equation agreed well with the experimental data. The relationship between solubility of candesartan cilexetil (Form I) and molar fraction of organic solvents (ethanol, acetonitrile and acetone) shown unimodal curves, and this phenomenon can be explained by Delta H-sol-Delta G(sol) compensation theory. For ethanol-water and acetonitrile-water mixture, the plot of Delta H-sol-Delta G(sol) compensation was nonlinear with positive and negative slopes, indicating that the increases of solubility were controlled by two different mechanisms (entropy and enthalpy). However, for acetone-water mixture, the plot of Delta H-sol-Delta G(sol) compensation was a linear curve, indicating that enthalpy is the dominant mechanism to control the solubility enhancement. These results can also be used to explain that acetone molecule played an important role in increasing the solute-solvent interactions of the candesartan cilexetil (Form I). (C) 2012 Elsevier B.V. All rights reserved. 
Solubility; Candesartan cilexetil; (NIBS)/Redlich-Kister equation; Enthalpy; Entropy