US EPA

3590025 

Journal Article 

First- and second-trimester thyroid hormone reference data in pregnant women: A FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study 

Lambert-Messerlian, G; McClain, M; Haddow, JE; Palomaki, GE; Canick, JA; Cleary-Goldman, J; Malone, FD; Porter, TF; Nyberg, DA; Bernstein, P; D'Alton, ME 

2008 

Yes 

American Journal of Obstetrics & Gynecology
ISSN: 0002-9378
EISSN: 1097-6868 

199 

1 

62.e1-62.e6 

English 

18585522 

10.1016/j.ajog.2007.12.003 

WOS:000257205200022 

has erratum 3593179 Correction:

OBJECTIVE: The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies.

STUDY DESIGN: TSH, free T4, and thyroid antibodies were measured in paired sera from 9562 women in the FaSTER trial of Down syndrome screening.

RESULTS: The median first trimester TSH (1.05 mIU/L) is lower than the second (1.23 mIU/L); and 98th centile is higher (4.15 vs 3.77 mIU/L). Within-woman paired TSH correlations are moderately strong (r(2) = 0.64). Among women with first trimester TSH values above the 98th centile, second trimester values are over the 95th centile in 68%. Median first trimester free T4 values (1.10 ng/dL) are higher than second (1.01 ng/dL). Paired free T4 measurements correlate weakly (r(2) = 0.23). Among women with first trimester free T4 values below the 2nd centile, second trimester values are below the 5th centile in 32%. Antibody measurements correlate strongly between trimesters (thyroperoxidase r(2) = 0.79, thyroglobulin r(2) = 0.83).

CONCLUSION: TSH and free T4 measurements require gestation-specific reference ranges.