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Citation
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HERO ID
3602994
Reference Type
Journal Article
Title
Wood combustion particles induce adverse effects to normal and diseased airway epithelia
Author(s)
Krapf, M; Künzi, L; Allenbach, S; Bruns, EA; Gavarini, I; El-Haddad, I; Slowik, JG; Prévôt, AS; Drinovec, L; Močnik, G; Dümbgen, L; Salathe, M; Baumlin, N; Sioutas, C; Baltensperger, U; Dommen, J; Geiser, M
Year
2017
Is Peer Reviewed?
Yes
Journal
Environmental Science: Processes & Impacts
ISSN:
2050-7887
EISSN:
2050-7895
Volume
19
Issue
4
Page Numbers
538-548
Language
English
PMID
28239691
DOI
10.1039/c6em00586a
Web of Science Id
WOS:000399908400007
URL
http://xlink.rsc.org/?DOI=C6EM00586A
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Abstract
Residential wood burning is a major source of poorly characterized, deleterious particulate matter, whose composition and toxicity may vary with wood type, burning condition and photochemical age. The causative link between ambient wood particle constituents and observed adverse health effects is currently lacking. Here we investigate the relationship between chemical properties of primary and atmospherically aged wood combustion particles and acute toxicity in human airway epithelial cells. Emissions from a log wood burner were diluted and injected into a smog chamber for photochemical aging. After concentration-enrichment and removal of oxidizing gases, directly emitted and atmospherically aged particles were deposited on cell cultures at the air-liquid interface for 2 hours in an aerosol deposition chamber mimicking physiological conditions in lungs. Cell models were fully differentiated normal and diseased (cystic fibrosis and asthma) human bronchial epithelia (HBE) and the bronchial epithelial cell line BEAS-2B. Cell responses were assessed at 24 hours after aerosol exposure. Atmospherically relevant doses of wood combustion particles significantly increased cell death in all but the asthma cell model. Expression of oxidative stress markers increased in HBE from all donors. Increased cell death and inflammatory responses could not be assigned to a single chemical fraction of the particles. Exposure to primary and aged wood combustion particles caused adverse effects to airway epithelia, apparently induced by several interacting components.
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