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3604671 
Journal Article 
Abstract 
7-Ethoxyresorufin O-deethylase and glutathione S-transferase activities of rats treated with morin, 7,12-dimethylbenz[a] anthracene and endosulfan 
Sapmaz, C; Firat, T; Kukner, A; Bozcaarmutlu, A 
2016 
1 
FEBS Journal
ISSN: 1742-464X
EISSN: 1742-4658 
283 
S1 
255-256 
English 
WOS:000383616901398 
Food dyes are used to impart, preserve or enhance the colour of food. Recently the use of artificial food dyes were increased. The aim of the this study was to investigate effects of artificial food dyes on oxidative stress status. A total of 18 adult female rats were categorized three groups as: G1 (n = 6) was fed basal diet and served as control, G2 (n = 6): basal diet + Amaranth (0.5 mg/kg) + Sunset Yellow FCF (2.5 mg/kg) + Allura Red AC (7 mg/kg) + Tartrazine (7.5 mg/kg) + Brilliant Blue FCF (12.5 mg/kg) + Ponceau 4R (4 mg/kg) +Azorubine (4 mg/kg) +Indigotine (5 mg/kg) + Erythrosine (0.1 mg/kg) andG3 (n = 6): basal diet + Amaranth (15 mg/kg) + Sunset Yellow FCF (250 mg/kg) + Allura Red AC (700 mg/kg) + Tartrazine (750 mg/kg) + Brilliant Blue FCF (600 mg/kg) + Ponceau 4R (70 mg/kg) + Azorubine (400 mg/kg) + Indigotine (500 mg/kg) + Erythrosine (10 mg/kg). Artificial food color mixture were administered to G2 and G3 and drinking water was applied simultaneously to G1 by oral gavage per day for 3 weeks. After application all rats were sacrificed, the total oxidant (TOS)/antioxidant (TAS) capacity were analyzed in rats’ brain, liver, kidney homogenate and serum with Rel TOS-TAS Diagnostics Assay kit.The statistical analysis was carried out by using Kruskal Wallis test. TAS and TOS levels in liver homogenate were not found significantly different between all groups (p > 0.05). In serum and kidney and brain homogenate, TAS levels were not significantly different between all groups. TOS levels in G3 were higher than G1 and G2 in serum and kidney and brain homogenate (p < 0.05). Exposure to synthetic food colors may increase oxidative stres in vitale organs such as brain, kidney in female rats. These alterations differ according to organ and dose.