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3612127 
Journal Article 
Investigation on Preparation of Methyl Isobutyl Ketone through the Reduction by Isopropanol 
Xu Lin; Wang Fang; Huang Jiejun; Xu Qing; Yu Lei; Fan Yining 
2016 
1 
Youji Huaxue / Chinese Journal of Organic Chemistry
ISSN: 0253-2786 
SCIENCE PRESS 
BEIJING 
36 
9 
2232-2235 
Chinese 
WOS:000387095600028 
The production capacity of acetone is excess in China at present. Conversion of acetone into high-value products with huge market demands is of practical value. Methyl isobutyl ketone (MIBK) is an important industrial intermediate with very broad applications and large market requirement. Thus, there are tremendous prospects for industrial applications for the synthesis of MIBK from acetone. This article reports a convenient access to MIBK from acetone through condensation and reduction procedures. Compared with conventional procedures, the method employed isopropanol as an alternative reductant to the dangerous H2 to reduce mesityl oxide (MO) into MIBK. The by-product from the reductant isopropanol was acetone and could be reused as the starting material to produce MO. After conditional optimizations, the MO conversion rate was enhanced to 95.8%, while the selectivity of MIBK was 98.8%. The two steps of reaction could be performed in one-pot. © 2016 Chinese Chemical Society & SIOC, CAS. 
Acetone; mesityl oxide (MO); catalysis; reduction; methyl isobutyl ketone (MIBK)