US EPA

3658194 

Journal Article 

Protection of animals against soman (1,2,2-trimethylpropyl methylphosphono-fluoridate) by pretreatment with some other organophosphorus compounds, followed by oxime and atropine 

Kogan, FM; Balagov, AG; Bunimovich, GI 

1970 

Yes 

Gigiena Truda i Professional'nye Zabolevaniya
ISSN: 0016-9919 

HEEP/72/10346 

14 

10 

45-47 

HEEP COPYRIGHT: BIOL ABS. The toxicity of carbamate and some organophosphorus inhibitors of acetylcholinesterase (EC 3.1.1.7) is not reduced by treatment with oximes and atropine. However, the toxicity of such compounds can be greatly reduced by prior administration of some other organophosphorus compounds, followed by oxime and atropine. The latter organophosphorus compounds must be such that their own toxicity is reduced by oxime and atropine. The most effective compound to confer protection when used in conjunction with oxime was ethyl-4-nitrophenyl methylphosphonate, which provided some protection for 48 hr. P2S (2-hydroxyiminomethyl-N-methylpyridinium methanesulfonate) was the only effective oxime of 7 examined. A number of cholinolytic drugs were tested in place of atropine, some of which were more effective, both in raising the LD50 of the challenging poison, soman (1,2,2-trimethylpropyl methylphosphonofluoridate) and in mitigating the severity of signs of poisoning. This form of treatment was most effective in the guinea pig, less so in the rabbit, and ineffective in the rat.