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3672899 
Journal Article 
Preparation, characterization, and in vitro drug release behavior of biodegradable chitosan-graft-poly(1, 4-dioxan-2-one) copolymer 
Liu, GY; Zhai, YL; Wang, XL; Wang, WT; Pan, YB; Dong, XT; Wang, YZ 
2008 
Yes 
Carbohydrate Polymers
ISSN: 0144-8617
EISSN: 1879-1344 
Carbohydrate Polymers 
74 
4 
862-867 
English 
WOS:000259765300017 
Abstract: A novel copolymer of chitosan-g-poly(p-dioxanone) (CGP) was synthesized in bulk by ring-opening polymerization of p-dioxanone (PDO) initiated by the hydroxyl group or amino group of chitosan using SnOct(2) as catalyst. The chemical structure was determined by (1)H NMR. It was found that the feed ratio of chitosan to PDO had a great effect on the degree of polymerization (DP) and the substitution (DS) of PDO. The thermal stability and crystallization behavior of graft copolymer CGP were closely related to the values of DP and DS. When the resulting copolymer was used as Ibuprofen carrier, the release rate of Ibuprofen decreased compared with that of pure chitosan carrier. The drug release behavior was also influenced by the structure of graft copolymers. (C) 2008 Elsevier Ltd. All rights reserved. ds: Agriculture cument Delivery No.: 356FY e field[29]: 1,4-Dioxane 
chitosan; p-dioxanone; graft copolymer; drug controlled release 
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