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3674189 
Journal Article 
A mild and efficient method for one-step alpha-haloacetalization of acetophenones using 1,3-dihalo-5,5-dimethylhydantoin in ethylene glycol 
Zheng, ZB; Li, ZZ; Han, BB; He, ZM; Shi, TF; Cheng, P 
2015 
1 
Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581 
Tetrahedron Letters 
56 
17 
2219-2222 
WOS:000353745900022 
Abstract: A mild and efficient method that could directly prepare alpha-haloacetal acetophenones from various acetophenones with 1,3-dihalo-5,5-dimethylhydantoin (DBDMH/DCDMH) and ethylene glycol in good yields without catalysts was reported. The effects of SOLVENT*s, 1,3-dihalo-5,5-dimethylhydantoin, and reaction temperature were investigated. Under the optimal condition, most of a-haloacetal acetophenones were obtained in 65-97% yields. (C) 2015 Elsevier Ltd. All rights reserved. ds: Chemistry cument Delivery No.: CH0XO e field[29]: 1,4-Dioxane 
Acetophenone; alpha-Haloacetalization; 1,3-Dihalo-5,5-dimethylhydantoin; Ethylene glycol; One-step