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3717042 
Journal Article 
Manganese terpyridine artificial metalloenzymes for benzylic oxygenation and olefin epoxidation 
Zhang, C; Srivastava, P; Ellis-Guardiola, K; Lewis, JC 
2014 
1 
Tetrahedron
ISSN: 0040-4020 
70 
27-28 
4245-4249 
English 
24904188 
WOS:000337990100021 
New catalysts for non-directed hydrocarbon functionalization have great potential in organic synthesis. We hypothesized that incorporating a Mn-terpyridine cofactor into a protein scaffold would lead to artificial metalloenzymes (ArMs) in which the selectivity of the Mn cofactor could be controlled by the protein scaffold. We designed and synthesized a maleimide-substituted Mn-terpyridine cofactor and demonstrated that this cofactor could be incorporated into two different scaffold proteins to generate the desired ArMs. The structure and reactivity of one of these ArMs was explored, and the broad oxygenation capability of the Mn-terpyridine catalyst was maintained, providing a robust platform for optimization of ArMs for selective hydrocarbon functionalization.