Mn-Zn Ferrite and Photosensitizer Co-loaded Cancer Theragnostic Agent for Magnetic Resonance Imaging and Photodynamic Therapy | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3722733

Reference Type

Journal Article

Title

Mn-Zn Ferrite and Photosensitizer Co-loaded Cancer Theragnostic Agent for Magnetic Resonance Imaging and Photodynamic Therapy

Author(s)

Lai, SyuM; Yang, MDa; Tung, MJue; Lai, PS

Year

2012

Page Numbers

226-229

Web of Science Id

WOS:000391249300058

Abstract

In this report, a multifunctional cancer diagnostic system based on manganese-zinc ferrite (MZF) and chlorin e6 (Ce6) co-loaded nanoclusters were demonstrated for magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The results showed that the MZF and Ce6 co-loaded nanoclusters with particle size around 100 nm exhibited almost non-toxic to the KB cells under 200 mu g Fe/ml and had better T2 relaxivity and darker T2-weighted MR images comparing to the commercial Resovist. Thus, this system may have highly potential diagnostic abilities for in nasopharyngeal cancer or other cancers.

Keywords

Manganese zinc ferrite; nano-clusters; magnetic resonance imaging; photodynamic therapy; theragonostic agents