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3723279 
Journal Article 
Syntheses of crystal structures and in vitro cytotoxic activities of new copper(II) complexes of pyridine-2,6-dicarboxylate 
Orhan, O; Colak, AT; Emen, FM; Kismali, G; Meral, O; Sel, T; Cilgi, GK; Tas, M 
2015 
Yes 
Journal of Coordination Chemistry
ISSN: 0095-8972
EISSN: 1029-0389 
68 
22 
4003-4016 
WOS:000362682600005 
[Cu(pydc)(im)](n) (1), [Cu(pydc)(mim)(3)].2H(2)O (2), [Cu(pydc)(ampy)(H2O)].H2O (3), and [Cu(pydc)(phen)][Cu(Hpydc)(2)] (4) (H(2)pydc=2,6-pyridinedicarboxylic acid or dipicolinic acid, im=imidazole, mim=2-methylimidazole, ampy=2-amino-4-methylpyridine, and phen=1,10-phenanthroline) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV-vis and IR spectra) and single crystal X-ray diffraction. Complexes 1, 2 and 3 were studied by thermogravimetric analysis from ambient temperature to 1100K under nitrogen and thermal stabilities were investigated. The effects of complexes on proliferation of fibrosarcoma cells were investigated using the Quick Cell Proliferation Assay. The cell viability changes depend on the concentrations and type of complexes. According to cell proliferation/viability data, 4 was determined to be the most cytotoxic. 
2; 6-Pyridinedicarboxylate; Crystal structure; Cytotoxic activity; Kinetic analysis