Synthesis of (3-(naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone and reaction with some nucleophiles for anticancer evaluation
Gouhar, RS; Raafat, E
| HERO ID | 3738331 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Synthesis of (3-(naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone and reaction with some nucleophiles for anticancer evaluation |
| Authors | Gouhar, RS; Raafat, E |
| Journal | Research on Chemical Intermediates |
| Volume | 41 |
| Issue | 8 |
| Page Numbers | 5529-5543 |
| Abstract | (3-(Naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone was prepared and allowed to react with different nucleophile agents such as hydrazine hydrate, phenyl hydrazine, methyl hydrazine, and hydroxylamine hydrochloride to give hydroxy pyrazole 2 and hydroxy oxazole 3. Also, oxirane 1 reacted with semicarbazide and thiosemicarbazide to give substituted pyrazole 4a,b. Also, oxirane 1 was allowed to react with carbon disulfide, glycine, substituted isothiocyanate, and thiourea to give compounds 5-8, respectively. The thiopyrimidine derivative 8 was cyclized by chloroacetic acid or ethyl bromoacetate to give thiazolidine derivative 9, which condensed with different aldehydes to give compound 10a-c. Some of these newly synthesized compounds were evaluated as anticancer agents. |
| Doi | 10.1007/s11164-014-1679-5 |
| Wosid | WOS:000357133500044 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Pyrazoles; Oxazoles; Thiopyrimidine; Thiazoles; Anticancer agent; Hep-G2 cells; CaCo-2 |