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3738331 
Journal Article 
Synthesis of (3-(naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone and reaction with some nucleophiles for anticancer evaluation 
Gouhar, RS; Raafat, E 
2015 
1 
Research on Chemical Intermediates
ISSN: 0922-6168
EISSN: 1568-5675 
41 
8 
5529-5543 
WOS:000357133500044 
(3-(Naphthalen-1-yl)oxiran-2-yl)(5,6,7,8-tetrahydronaphthalen-2-yl)methanone was prepared and allowed to react with different nucleophile agents such as hydrazine hydrate, phenyl hydrazine, methyl hydrazine, and hydroxylamine hydrochloride to give hydroxy pyrazole 2 and hydroxy oxazole 3. Also, oxirane 1 reacted with semicarbazide and thiosemicarbazide to give substituted pyrazole 4a,b. Also, oxirane 1 was allowed to react with carbon disulfide, glycine, substituted isothiocyanate, and thiourea to give compounds 5-8, respectively. The thiopyrimidine derivative 8 was cyclized by chloroacetic acid or ethyl bromoacetate to give thiazolidine derivative 9, which condensed with different aldehydes to give compound 10a-c. Some of these newly synthesized compounds were evaluated as anticancer agents. 
Pyrazoles; Oxazoles; Thiopyrimidine; Thiazoles; Anticancer agent; Hep-G2 cells; CaCo-2