Synthesis, Partition coefficient and antibacterial activity of 3 '-aryl-6 '-phenyl(substituted)-cis-5 ' a,6 '-dihydrospiro[3H-indole-3,4 '-thiozolo(5 ',1 '-c)-isoxazolo-2-(1H)-ones] | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3742737

Reference Type

Journal Article

Title

Synthesis, Partition coefficient and antibacterial activity of 3 '-aryl-6 '-phenyl(substituted)-cis-5 ' a,6 '-dihydrospiro[3H-indole-3,4 '-thiozolo(5 ',1 '-c)-isoxazolo-2-(1H)-ones]

Author(s)

Sahu, SK; Mishra, SK; Banerjee, M; Panda, PK; Misro, PK

Year

2006

Is Peer Reviewed?

Yes

Journal

Journal of the Indian Chemical Society
ISSN: 0019-4522

Volume

Issue

Page Numbers

725-727

Web of Science Id

WOS:000239739400019

Abstract

Condensation of isatin with primary aryl amines gave a series of Schiff bases (1) which on reaction with thioglycolic acid in 1,4-dioxane afforded the corresponding thiazolidones (2). Compound 2 on condensation with substituted benzaldehydes in anhydrous sodium acetate furnished 3-aryl-5'-phenyl(substituted)spiro[3H-indole-3,2-thiazolidines]-2-(1H), 4'(5H))-diones (3). The latter on reaction with hydroxylamine. hydrochloride In anhydrous sodium acetate gave the title compounds (4). The structures have been established on the basis of spectral data. The Partition coefficient for n-octanol/water solvent system and in vitro antibacterial activity of this compounds have been evaluated.<

Keywords

Schiff base; Partition coefficient; log p