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3745209 
Journal Article 
One-pot synthesis of isoxazolines using soluble polymer-supported acrylates 
Tao, L; Zhang, PF; Gu, YX 
2005 
1 
Chinese Chemical Letters
ISSN: 1001-8417
EISSN: 1878-5964 
16 
4 
440-442 
WOS:000228574100005 
An efficient and rapid parallel liquid-phase synthesis of isoxazolines has been reported. The one-pot three-component reaction of polyethylene glycol-supported acrylates, aldehydes and hydroxylamine hydrochloride in the presence of chloramine-T in methanol gave the corresponding PEG-supported isoxazolines, which can be cleaved from the support under mild condition to afford isoxazolines in good yields (> 80%) and high purities (> 86%). 
isoxazolines; 1,3-dipolar cycloaddition; soluble polymer; liquid-phase synthesis; polythylene glycol