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3763428 
Journal Article 
Synthesis and antimicrobial elucidation of [1,2,4]-triazole-3-thione derivatives 
Godhani, DR; Sanghani, AM; Sanja, DB; Dobariya, PB 
2012 
Yes 
Journal of the Indian Chemical Society
ISSN: 0019-4522 
Indian Chemical Society 
89 
7 
971-974 
English 
WOS:000307412600016 
4-Nitro benzoyl isothiocyanate (1) is prepared by a reaction of 4-nitro benzoyl chloride and ammonium isothiocyanate. Compound 1 reacts with phenyl hydrazine in the presence of acetone to form 5-(4-nitrophenyl)-1-phenyl-1H-1,2,4-triazole-3(211)-thione (2). Compounds 2 on reaction with formaldehyde and different aromatic amines in 1,4-dioxane yielded 2-(substituted-amino)methyl-5-(4-nitrophenyl)-1-phenyl-1H-1,2,4-triazole-3(2H)-thione (3a-j) respectively. The synthesized compound 3a-j were screened for their antibacterial and antifungal activities and characterized by spectral techniques like IR and NMR. 
Acid chloride; aryl hydrazine; ammonium thiocyanate; 1,2,4-triazole-3-thione; Mannich reaction; mercapto-1,2,4-triazole