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HERO ID
3784280
Reference Type
Journal Article
Title
Final report on the safety assessment of cetrimonium chloride, cetrimonium bromide, and steartrimonium chloride
Author(s)
Andersen, FA
Year
1997
Is Peer Reviewed?
Yes
Journal
International Journal of Toxicology
ISSN:
1091-5818
EISSN:
1092-874X
Report Number
BIOSIS/98/24863
Volume
16
Issue
3
Page Numbers
195-220
Language
English
Abstract
BIOSIS COPYRIGHT: BIOL ABS. Cetrimonium bromide, Cetrimonium chloride, and Steartrimonium Chloride are quaternary ammonium salts used for a variety of purposes in cosmetics at concentrations of up to 10%. Cetrimonium bromide given orally is poorly absorbed from the intestine and is excreted in feces. Cetrimonium bromide applied dermally is absorbed into the skin, but not rapidly. Dermal irritation and sensitization and ocular irritation are seen with these quaternary ammonium salts. Cetrimonium bromide was embryotoxic and teratogenic in mice following intraperitoneal injection of 35 mg/kg; only teratogenic effects were observed with 10 mg/kg. Embryotoxic effects consistent with maternal toxicity were seen in a rat-feeding study using 50 mg/kg/day. Dermal exposure to 2% Cetrimonium chloride produced no evidence of teratogenicity; nor did 2.5% Steartrimonium chloride. All mutagenesis assays used were negative. Repeated insult patch tests of concentrations of up to 0.25% Cetrimonium Chloride produced
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