US EPA

3806647 

Technical Report 

Carcinogenicity of N-nitroso derivatives of N-methylcarbamate insecticides in rats 

Lijinsky, W; Schmaehl, D 

1978 

Yes 

Ecotoxicology and Environmental Safety
ISSN: 0147-6513
EISSN: 1090-2414 

PESTAB/79/1882 

Environ 

3-4 

413-419 

English 

10.1016/S0147-6513(78)80014-1 

PESTAB. Mortality and tumor incidence of rats treated with nitrosoated methylcarbamate insecticides is described. Groups of 16 male and 16 female Sprague-Dawley rats were initially given solutions of the nitroso compounds by gavage at the rate of 60 mg/kg/wk for 10 wk (total dose equivalent to 600 mg of carbaryl per kg over the treatment period). Because some compounds (nitrosobaygon (propoxur), nitrosocarbofuran) proved too toxic, their doses were lowered to 25% of the original dosage. All of the nitroso- N-methylcarbamates tested proved to be carcinogenic. The majority of tumors were carcinomas of the stomach. The order of carcinogenic efficacy (based on number of animals with tumors) was nitrosobaygon = nitrosocarbofuran and gt; nitrosolandrin and gt; nitrosocarbaryl and gt; nitroso-Buxten (bufencarb) and gt; nitrosomethomyl and gt; nitrosoaldicarb. Formation of nitrosomethylcarbamates from parent insecticides with nitrites in the stomach can lead to increased risks of carcinogenesis. 

3,4,5 trimethylphenyl methylcarbamate; aldicarb; bux ten; carbamic acid methyl ester; carbofuran; insecticide; methomyl; propoxur; unclassified drug; animal experiment; carcinogenesis; drug comparison; drug screening; drug toxicity; histology; intoxication; liver; n methyl n nitrosocarbamic acid derivative; n nitrosocarbamic acid methyl ester; n nitrosopropoxur; nitrosoaldicarb; nitrosobuxten; nitrosocarbaril; nitrosocarbofuran; nitrosolandrin; nitrosomethomyl; oral drug administration; rat; stomach; Aldicarb; Animal; Carbaryl; Carbofuran; Carcinogens; Female; Insecticides, Carbamate; Male; Methomyl; Nitroso Compounds; Rats; Time Factors