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3829098 
Journal Article 
Yb(OTf)(3)-catalyzed Mannich reaction of imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyrimidines 
Pericherla, K; Shelke, GM; Kothari, YC; Kumar, A 
2015 
1 
Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983 
54 
2 
290-300 
English 
WOS:000351331300010 
An efficient one-pot condensation reaction of imidazo[1,2-a]pyridine/pyrazolo[1,5-a] pyrimidines, aldehydes and acetamide has been investigated using Yb(OTf)(3) as catalyst in 1,4-dioxane. The reaction furnishes good to excellent yield of 1-amidomethyl-imidazo[1,2-a]pyridines and 1-amidomethyl-pyrazolo[1,5-a]pyrimidines along with small quantities of bis(imidazo[1,2-a]pyridyl)methanes and bis(pyrazolo[1,5-a]pyrimidinyl)methanes. The product distribution is found to be dependent on the nature of imidazo[1,2-a]pyridine/ pyrazolo[1,5-a]pyrimidines and aldehydes. 
Multicomponent reaction; imidazo[1,2-a]pyridine; pyrazolo[1,5-cdpyrimidine; ytterbium triflate; one-pot synthesis