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3829881 
Journal Article 
Preparation and properties of a novel solution of hydrogen bromide (HBr) in 1,4-dioxane: An alternative reagent to HBr gas without protic solvents 
Nishio, Y; Mifune, R; Sato, T; Ishikawa, S; Matsubara, H 
2017 
1 
Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581 
Elsevier Ltd 
58 
12 
1190-1193 
English 
WOS:000397376600024 
A solution of hydrogen bromide (HBr) in 1,4-dioxane was prepared and investigated for its ability to brominate alcohols, and hydrobrominate alkenes. This study revealed that the brominating ability of this HBr/1,4-dioxane solution is equal or superior to that of hydrobromic acid or HBr in acetic acid. The solution of HBr in 1,4-dioxane is robust, exhibiting no decomposition of the solvent, and retaining 97% of its original concentration, when kept at 25 degrees C for 30 days. This solution is a liquid alternative to HBr gas without protic solvents. (C) 2017 Elsevier Ltd. All rights reserved. 
Hydrogen bromide solution; 1,4-Dioxane; Bromination of alcohols; Hydrobromination of alkenes; 1,3-Dioxolane