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3829904 
Journal Article 
Simple Synthesis of Bicyclic Pyrrole Ketone Compounds 
Kong Lingbin; Yang Ruixia; Du Xuanxuan; Yan Shengjiao; Lin Jun 
2016 
1 
Youji Huaxue / Chinese Journal of Organic Chemistry
ISSN: 0253-2786 
36 
10 
2437-2441 
WOS:000389394000016 
In this article, a one-pot protocol was established for the synthesis of bicyclic pyrrole ketone compounds. This method based on the building blocks of heterocyclic ketene aminals 1, which reacted with oxalaldehyde 2 in 1,4-dioxane at 50 degrees C and triethylamine as base. As a result, a series of bicyclic pyrrole ketone compounds 3a similar to 31 have been synthesized. This reaction has some advantages such as simple synthetic route, readily available starting materials, high yields and simple work-up procedures. 
bicyclic pyrrole ketone; heterocyclic ketene aminals; oxalaldehyde