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HERO ID
3829923
Reference Type
Journal Article
Title
Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles
Author(s)
Ben-Yahia, Ali; Naas, M; El Brahmi, N; El Kazzouli, S; Majoral, JP; Essassi, ElM; Guillaumet, G
Year
2013
Is Peer Reviewed?
Yes
Journal
Current Organic Chemistry
ISSN:
1385-2728
EISSN:
1875-5348
Volume
17
Issue
3
Page Numbers
304-309
DOI
10.2174/1385272811317030011
Web of Science Id
WOS:000317867000010
Abstract
Suzuki-Miyaura cross-coupling of free (NH) indazoles is described. The reactions are carried out under microwave irradiation using various 3-bromoindazoles and boronic acids. Different reaction conditions were investigated and the best results were obtained using Pd(PPh3)(4) and Cs2CO3 in a mixture of 1,4-dioxane/EtOH/H2O at 140 degrees C under microwave irradiation.
Keywords
Suzuki-Miyaura cross-coupling; Free (NH) indazoles; Microwave irradiation; Palladium-mediated cross-coupling; Boronic acids
Tags
OPPT REs
•
OPPT_1,4-Dioxane_D. Exposure
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