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3830608 
Journal Article 
Efficient One-Pot Synthesis of Diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5,9-trione Derivatives under Solvent-Free and Catalyst-Free 
Xu Zhaohui; Zhou Peng; Lin Chunhua; Liu Deyong 
2016 
1 
Youji Huaxue / Chinese Journal of Organic Chemistry
ISSN: 0253-2786 
36 
8 
1948-1953 
WOS:000385057000026 
Twelve kinds of diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5,9-trione derivatives were synthesized by the three-component one-pot reaction of aromatic aldehydes with urea and 2,2-butylidene-1,3-dioxane-4,6-dione or 2,2-pentylidene-1,3-dioxane-4,6-dione under solvent-free and catalyst-free. The yields ranged from 49% to 63%. Its advantages were no solvent pollution and mild reaction conditions. Furthermore, a proposed reaction mechanism for this condensation reaction was speculated and the relationship between reaction speed and substituent groups was also described. All the compounds synthesized were confirmed by H-1 NMR, C-13 NMR, ESI-MS and IR techniques. 
three-component reaction; diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5,9-trione derivatives; solvent-free; catalyst-free