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3831146 
Journal Article 
Development of approaches to fibrostatin F, N-acetyl-L-cysteinyl-containing 1,4-naphthoquinone metabolite of Streptomyces catenulae 
Sabutskii, YuE; Denisenko, VA; Dmitrenok, PS; Polonik, SG 
2016 
1 
Russian Chemical Bulletin
ISSN: 1066-5285
EISSN: 1573-9171 
65 
3 
774-778 
WOS:000391826700028 
A possibility of the synthesis of microbial metabolite Streptomyces catenulae fibrostatin F through the AcOH-catalyzed condensation of 5-hydroxy-3-hydroxymethyl-2,7-dimethoxy1,4-naphthoquinone and its related 3-chloromethyl, 3-acetoxymethyl, and 3-methoxymethyl derivatives with N-acetyl-L-cysteine and paraformaldehyde in 1,4-dioxane was studied. In these conditions, all naphthoquinones gave N-acetyl-S-[(8-hydroxy-3,6-dimethoxy-1,4-dioxonaphthalen-2-yl)methyl]-L-cysteine isomeric to the natural fibrostatin C. 
fibrostatins; N-acetyl-L-cysteine; 5-hydroxy-2,7-dimethoxy-3-methyl-1,4-naphthoquinones; N-acetyl-S-[(8-hydroxy-3,6-dimethoxy-1,4-dioxonaphthalen-2-yl) methyl]-L-cysteine; Streptomyces catenulae