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3842906 
Journal Article 
THE METABOLISM OF TESTOSTERONE BY TISSUE FROM NORMAL AND NEOPLASTIC RAT BREAST 
King, RJ; Gordon, J; Helfenstein, JE 
1964 
Yes 
Journal of Endocrinology
ISSN: 0022-0795
EISSN: 1479-6805 
29 
103-110 
English 
14170383 
SUMMARY The qualitative and quantitative metabolism of testosterone by rat mammary gland and hydrocarbon-induced mammary tumours has been investigated. These tissues contain a Δ 4 -5α-hydrogenase, 3-ketosteroid reductase and 17 β-hydroxysteroid dehydrogenase. The qualitative picture was the same in all the tissues studied but a quantitative difference was evident. In general, the tumours metabolized more steroid than mammary gland tissue taken from animals in late pregnancy. No conversion of testosterone to oestrone or oestradiol could be detected.