Diesel engines have advantages due to their potential for high fuel conversion efficiency. However, it is necessary to reduce pollutant emissions, particularly NOx and soot to meet emission mandates. Many studies have shown that oxygenated fuel additives can effectively reduce soot emissions. In this research, to investigate the effect of oxygenated fuel properties on combustion and soot emission, CFD simulations were carried out using newly developed chemical mechanisms for various oxygenated fuels such as tripropylene glycol methyl ether, methyl decanoate, and dimethyl ether. The results show that the formation of soot precursors decreases with increased oxygen content and decreased number of C-C bonds in the fuel. The fuel molecular structure strongly affects soot formation in addition to fuel-air mixing. Comparisons of fuel blends (oxygenated fuels with n-hexadecane) including methyl decanoate, which have the same fuel oxygen ratio, show that the effects of the ignition delay and lift-off length control soot formation for fuels with similar fuel oxygen ratio and number of C-C bonds. (C) 2016 The Combustion Institute. Published by Elsevier Inc. All rights reserved.