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HERO ID
3859087
Reference Type
Journal Article
Title
Wastewater-based epidemiology as a new tool for estimating population exposure to phthalate plasticizers
Author(s)
González-Mariño, I; Rodil, R; Barrio, I; Cela, R; Quintana, JB
Year
2017
Is Peer Reviewed?
1
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Publisher
American Chemical Society
Volume
51
Issue
7
Page Numbers
3902-3910
Language
English
PMID
28240866
DOI
10.1021/acs.est.6b05612
Web of Science Id
WOS:000398646500036
Abstract
This study proposes the monitoring of phthalate metabolites in wastewater as a nonintrusive and economic alternative to urine analysis for estimating human exposure to phthalates. To this end, a solid-phase extraction-liquid chromatography-tandem mass spectrometry method was developed, allowing for the determination of eight phthalate metabolites in wastewater (limits of quantification between 0.5 and 32 ng L(-1)). The analysis of samples from the NW region of Spain showed that these substances occur in raw wastewater up to ca. 1.6 μg L(-1) and in treated wastewater up to ca. 1 μg L(-1). Concentrations in raw wastewater were converted into levels of exposure to six phthalate diesters. For two of them, these levels were always below the daily exposure thresholds recommended by the U.S. Environmental Protection Agency and the European Food Safety Authority. For the other four, however, estimates of exposure surpassed such a threshold (especially the toddler threshold) in some cases, highlighting the significance of the exposure to phthalates in children. Finally, concentrations in wastewater were also used to estimate metabolite concentrations in urine, providing a reasonable concordance between our results and the data obtained in two previous biomonitoring studies.
Keywords
Excretion; Anatomy; Metabolism; Wastewater; Organic compounds
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
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