Air pollution and genomic instability: The role of particulate matter in lung carcinogenesis | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3861892

Reference Type

Journal Article

Subtype

Review

Title

Air pollution and genomic instability: The role of particulate matter in lung carcinogenesis

Author(s)

Santibáñez-Andrade, M; Quezada-Maldonado, EM; Osornio-Vargas, Á; Sánchez-Pérez, Y; García-Cuellar, CM

Year

2017

Is Peer Reviewed?

Yes

Journal

Environmental Pollution
ISSN: 0269-7491
EISSN: 1873-6424

Volume

229

Page Numbers

412-422

Language

English

PMID

28622661

DOI

10.1016/j.envpol.2017.06.019

Web of Science Id

WOS:000410010200043

Abstract

In this review, we summarize and discuss the evidence regarding the interaction between air pollution, especially particulate matter (PM), and genomic instability. PM has been widely studied in the context of several diseases, and its role in lung carcinogenesis gained relevance due to an increase in cancer cases for which smoking does not seem to represent the main risk factor. According to epidemiological and toxicological evidence, PM acts as a carcinogenic factor in humans, inducing high rates of genomic alterations. Here, we discuss not only how PM is capable of inducing genomic instability during the carcinogenic process but also how our genetic background influences the response to the sources of damage.