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3895172 
Journal Article 
Review 
Simultaneous occurrence of type 1 diabetes mellitus and Graves' disease: a report of two cases and a review of the literature 
Mizokami, T; Yamauchi, A; Sato, Y; Toyonaga, M; Imoto, H; Kojima, H; Saji, H; Nunoi, K 
2013 
Yes 
Internal Medicine
ISSN: 0918-2918
EISSN: 1349-7235 
JAPAN SOC INTERNAL MEDICINE 
TOKYO 
52 
22 
2537-2543 
English 
24240794 
WOS:000327938800011 
Two unrelated Japanese women, 41 and 27 years of age, were admitted with histories of thirst, weight loss and palpitations of a few weeks' duration. Both were diagnosed to have diabetic ketosis or ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune polyglandular syndrome type 3 variant; APS3v), and were treated with intensive insulin therapy and anti-thyroid drugs. Human leukocyte antigen examinations showed that both cases had the HLA-A2, A24, B54, and DRB1*04:05-DQA1*03:03-DQB1*04:01 haplotype, which made them susceptible not only to APS3v, but also to both acute-onset T1D and GD. The genetic background of patients strongly contributes to the simultaneous occurrence of T1D and GD. 
Graves' disease; diabetes mellitus; autoimmune polyglandular syndrome; human leukocyte antigen