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Citation
Tags
HERO ID
3928054
Reference Type
Journal Article
Subtype
Review
Title
Diagnosis and classification of autoimmune gastritis
Author(s)
Toh, BH
Year
2014
Is Peer Reviewed?
Yes
Journal
Autoimmunity Reviews
ISSN:
1568-9972
EISSN:
1873-0183
Volume
13
Issue
4-5
Page Numbers
459-462
Language
English
PMID
24424193
DOI
10.1016/j.autrev.2014.01.048
Web of Science Id
WOS:000333775700026
Abstract
Autoimmune gastritis is a silent and highly prevalent disease that only becomes clinically manifested with progression to corpus atrophy and development of iron deficient or B12-deficient (pernicious) anaemia. Autoimmune gastritis is associated with autoimmune thyroiditis and type 1 diabetes mellitus. Corpus atrophy may be complicated by gastric carcinoids and gastric cancer. Laboratory diagnosis of autoimmune gastritis rests on serum biomarkers of antibody to parietal cell H/K ATPase and intrinsic factor and corpus atrophy on serum biomarkers of gastrin and pepsinogen levels. Subjects with asymptomatic parietal cell antibody should be regularly assessed for serum biomarkers for progression to corpus atrophy, development of iron and B12 deficiency anaemia and for associated autoimmune thyroiditis and type 1 diabetes mellitus.
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