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3964275 
Journal Article 
Small bowel bacterial overgrowth and type 1 diabetes 
Ojetti, V; Pitocco, D; Scarpellini, E; Zaccardi, F; Scaldaferri, F; Gigante, G; Gasbarrini, G; Ghirlanda, G; Gasbarrini, A 
2009 
1 
European Review for Medical and Pharmacological Sciences
ISSN: 1128-3602 
13 
6 
419-423 
WOS:000272628700003 
Background: Gastrointestinal motility disorders are often present in diabetic patients (pts). Such motility dysfunctions have been attributed to autonomic neuropathy. Impaired intestinal motility is often associated with small-bowel bacterial overgrowth (SIBO) but only few studies evaluated the relationship between autonomic neuropathy and SIBO in diabetic pts.



Aim: To compare the prevalence of SIBO between type 1 diabetic (T1D) pts with and without autonomic neuropathy.



Patients and Methods: 25 pts (13 males, 12 females; mean age 44.2+/-7) affected by type 1 diabetes with normal cardiovascular autonomic test (group A) and 25 type 1 diabetic pts with abnormal cardiovascular autonomic test (group B) were submitted to hydrogen lactulose breath test.



Results: 2 out of 25 (8%) showed SIBO among group A, while 11 out of 25 (44%) showed SIBO among group B (p<0.01). Interestingly, among group B, the daily insulin requirements was significantly higher in SIBO-positive pts compared to SIBO-negative: 0.66+/-0.3 vs. 0.59+/-0.1 UI/kg (p<0.05).



Conclusions: Pts with autonomic neuropathy have a significantly higher prevalence of SIBO, that is also associated with a higher daily insulin requirements. 
Type 1 diabetes; Diabetic autonomic neuropathy; Small bowel bacterial overgrowth; Insulin requirement