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HERO ID
4000269
Reference Type
Journal Article
Title
Chitosan-based membranes with different ionic crosslinking density for pharmaceutical and industrial applications
Author(s)
Gierszewska, M; Ostrowska-Czubenko, J
Year
2016
Is Peer Reviewed?
Yes
Journal
Carbohydrate Polymers
ISSN:
0144-8617
EISSN:
1879-1344
Volume
153
Page Numbers
501-511
Language
English
PMID
27561522
DOI
10.1016/j.carbpol.2016.07.126
Web of Science Id
WOS:000382317200058
Abstract
Chitosan membranes (Ch), ionically crosslinked with pentasodium tripolyphosphate (TPP), were prepared using chitosan of medium and high molecular weight of similar degree of deacetylation and different crosslinking conditions. An effect of synthesis conditions (pH of crosslinking TPP solution equal to 5.5 and 9.0) on molecular and supermolecular structure and on crosslinking density of Ch/TPP membranes was confirmed using Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD) method and energy dispersive X-ray (EDX) spectrometry. Atomic-force microscopy (AFM) and contact angle measurements indicated some differences in membrane roughness and hydrophilicity. The state of water in non-crosslinked and ionically crosslinked Ch membranes containing different amount of water was investigated by low temperature differential scanning calorimetry (DSC) measurements. DSC analysis confirmed presence of freezing and non-freezing water in non-crosslinked and ionically crosslinked membranes. The amount of non-freezing water generally decreased after Ch crosslinking and was affected by crosslinking conditions and crosslinking density. Molecular weight of Ch had only slight influence on all characterized properties of ionically crosslinked membranes.
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