Carcinogenicity of p-chloro-benzotrichloride, Proc of Japan Assoc of Ind Health pp 330-331, 1979, as reported and translated in: Letter from Hooker Chem and plastics corp to USEPA regarding information on the possible carcinogenicity of benzotrichloride, p-chlorobenzotrichloride and benzoyl chloride w-attachment | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

4017189

Reference Type

Technical Report

Subtype

TSCA Submission

Title

Carcinogenicity of p-chloro-benzotrichloride, Proc of Japan Assoc of Ind Health pp 330-331, 1979, as reported and translated in: Letter from Hooker Chem and plastics corp to USEPA regarding information on the possible carcinogenicity of benzotrichloride, p-chlorobenzotrichloride and benzoyl chloride w-attachment

Author(s)

Fukuda, K; Matsushita, S; Takemoto, K

Year

1980

Publisher

Submitted to the U.S. Environmental Protection Agency by Hooker Chemical Company

Report Number

TSCATS/408799, OTS0204867, Doc #86-8000116, 8EHQ-0980-0360

Language

English

Abstract

Benzotrichloride, benzoyl chloride and 4- chlorobenzotrichloride were evaluated for chronic toxicity/carcinogenicity. Four Japanese reports and their English translations are presented. Female mice (8 to 12/group) were exposed to 1.6 ppm benzotrichloride 2x/week for 30 minutes over a 12 month period at room temperature or at 50 degrees Celsius, followed by an observation period of 12 or 15 months. Significant mortality resulted. Room temperature exposure caused pulmonary tumors (adenoma and adenocarcinoma). In all exposure groups, severe chronic bronchitis and bronchial pneumonia, skin papilloma and epidermoid carcinoma, kera