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HERO ID
4074463
Reference Type
Journal Article
Title
Effects of MAO inhibition and a combination of minor alkaloids, β-carbolines, and acetaldehyde on nicotine self-administration in adult male rats
Author(s)
Smith, TT; Schaff, MB; Rupprecht, LE; Schassburger, RL; Buffalari, DM; Murphy, SE; Sved, AF; Donny, EC
Year
2015
Is Peer Reviewed?
Yes
Journal
Drug and Alcohol Dependence
ISSN:
0376-8716
Volume
155
Page Numbers
243-252
Language
English
PMID
26257022
DOI
10.1016/j.drugalcdep.2015.07.002
Web of Science Id
WOS:000362307000035
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941932500&doi=10.1016%2fj.drugalcdep.2015.07.002&partnerID=40&md5=2cd6c8e085d119632b9884defaba72ab
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Abstract
INTRODUCTION:
Although nicotine is the primary reinforcing constituent in cigarettes, there is evidence that other constituents in cigarette smoke may interact with nicotine to reinforce smoking behavior.
METHODS:
The present experiments investigated whether a novel combination of these cigarette smoke constituents would increase nicotine self-administration in adult male rats. The constituents included five minor alkaloids (anabasine, nornicotine, cotinine, myosmine, and anatabine), two β-carbolines (harman and norharman), and acetaldehyde. All doses were indexed to be proportional to concentrations in cigarette smoke given a standard dose of nicotine used in rodent self-administration, or ten times higher than this standard. To model MAO inhibition seen in chronic smokers, some groups received separate injections of tranylcypromine prior to each self-administration session.
RESULTS:
Tranylcypromine increased low-dose nicotine self-administration independent of other smoke constituents, which had no effect on self-administration behavior. The effect of tranylcypromine was confirmed across a large range of reinforcement schedules. The effect of tranylcypromine on low-dose nicotine self-administration was observed regardless of whether the injection was delivered 1-h or 23-h prior to the self-administration session, consistent with the interpretation that MAO inhibition was responsible for the increase in self-administration, instead of acute off-target effects.
CONCLUSIONS:
These data suggest that this cocktail of constituents does not significantly alter the primary reinforcing effects of nicotine, but constituents that inhibit MAO may increase the primary reinforcing effects of nicotine, especially at low doses.
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