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4081742 
Book/Book Chapter 
Chapter 9: Liver and Pancreas 
Greaves, P 
2012 
Elsevier Science 
Amsterdam, Netherlands 
Histopathology of preclinical toxicity studies: Interpretation and relevance in drug safety evaluation 
433–535 
English 
is a chapter of 2919080 Histopathology of preclinical toxicity studies: Interpretation and relevance in drug safety evaluation
The purpose of this chapter is to discuss the importance of the pathologic alterations that can be induced by drugs in the liver of laboratory animals and their implication for hepatic toxicity in patients. It describes anatomy and physiology of the liver of the laboratory species in some detail and discusses how these may differ from humans. Drug-induced hepatic alterations described include changes to hepatic weight, hypertrophy, hyperplasia, storage disorders, pathology of the bile duct and gallbladder as well as the frequently occurring neoplasms in the rodent liver and their implications for human therapy. The chapter also describes a similar range of changes that can be seen in the exocrine pancreas and the endocrine alterations in the islets of Langerhans. 
4th 
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