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HERO ID
4082335
Reference Type
Journal Article
Title
Manganese content of large-volume parenteral solutions and of nutrient additives
Author(s)
Kurkus, J; Alcock, NW; Shils, ME
Year
1984
Is Peer Reviewed?
Yes
Journal
Journal of Parenteral and Enteral Nutrition
ISSN:
0148-6071
Volume
8
Issue
3
Page Numbers
254-257
Language
English
PMID
6429361
DOI
10.1177/0148607184008003254
Web of Science Id
WOS:A1984SS25400004
Abstract
Manganese (Mn) was analyzed by flameless atomic absorption spectrophotometry in a variety of commercially produced solutions and additives commonly used in total parenteral nutrition (TPN). The amount of Mn in preparations tested varied among manufacturers and among lots. It was generally present in very small amounts with amino acid preparations supplying the major portion in the TPN formulas. Among amino acid solutions, Aminosyn 10% had the highest Mn content (5.2-17.0 micrograms/liter) with Veinamine 8%, FreAmine II, 8.5%, Travasol 10%, and Nephramine having less than 6.7 micrograms/liter. Other large volume parenterals contained appreciably less Mn, eg, Dextrose 50% had 0.64-2.5 micrograms/liter. Some of the additives were high in Mn, eg, potassium phosphate--280 micrograms/liter, magnesium sulfate 50%--up to 225 micrograms/liter, and Berocca C--245.8 micrograms/liter but their actual contributions to daily TPN intake was no more than 3.3 micrograms. The calculated Mn content in TPN formulas with varying source materials ranged from 8.07-21.75 micrograms per total daily volume. These values agreed with those obtained from analysis of actual TPN solutions. The values for 10% Intralipid and 20% Liposyn were 0.5 and 3.0 micrograms/liter, respectively.
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