TNFA -308g and gt; A Polymorphism Influences The TNF- Response To Altered Vaginal Flora And Pregnancy Outcome | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4090166

Reference Type

Journal Article

Title

TNFA -308g and gt; A Polymorphism Influences The TNF- Response To Altered Vaginal Flora And Pregnancy Outcome

Author(s)

Genc, MR; Vardhana, S; Delaney, ML; Witkin, S; Onderdonk, A

Year

2004

Is Peer Reviewed?

Yes

Journal

American Journal of Obstetrics & Gynecology
ISSN: 0002-9378
EISSN: 1097-6868

Report Number

DART/TER/5000252

Volume

191

Issue

6 Suppl

Language

English

Abstract

OBJECTIVE: To investigate the association between a tumor necrosis factor-alpha (TNF-alpha) gene polymorphism, mid-trimester vaginal TNF-alpha levels, microbial flora, and pregnancy outcome. STUDY DESIGN: Vaginal samples from 203 women at 18-22 weeks and #146; gestation were analyzed for microflora, TNFA-308 G and gt; A polymorphism, and TNF-alpha concentration. Outcome data were subsequently obtained. RESULTS: TNFA -308A carriers with bacterial vaginosis (BV) had higher median TNF-alpha levels (10.94 pg/mL) than did TNFA-308A carriers without BV (1.77 pg/mL, P = .02) or TNFA-308G homozygotes with BV (1.72 pg/ml, P = .01). Among black, but not white or Hispanic women, TNFA -308A carriage was associated with preterm delivery (odds ratio = 17; 95% CI = 1.05 - 917.25) and low birthweight (2954g vs. 3376g) (P = .02). CONCLUSION: TNFA -308A carriage is associated with an exaggerated TNF-alpha response to BV-associated vaginal flora and, in black women, with spontaneous preterm delivery and low birthweight.