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4093956 
Journal Article 
Ostene, a new alkylene oxide copolymer bone hemostatic material, does not inhibit bone healing 
Magyar, CE; Aghaloo, TL; Atti, E; Tetradis, S 
2008 
1 
Neurosurgery
ISSN: 0148-396X 
63 
4 Suppl 2 
373-8; discussion 378 
English 
18981846 
OBJECTIVE: In this study, we investigate the effects of a soft bone hemostatic wax comprised of water-soluble alkylene oxide copolymers (Ostene; Ceremed, Inc., Los Angeles, CA) on bone healing in a rat calvaria defect model. We compared the effects with a control (no hemostatic agent) and bone wax, an insoluble and nonresorbable material commonly used for bone hemostasis.

METHODS: Two bilateral 3-mm circular noncritical-sized defects were made in the calvariae of 30 rats. Alkylene oxide copolymer or bone wax was applied or no hemostatic material was used (control). After 3, 6, and 12 weeks, rats were sacrificed and the calvariae excised. Bone healing, expressed as fractional bone volume (+/- standard error of the mean), was measured by microcomputed tomography.

RESULTS: Immediate hemostasis was achieved equally with bone wax and alkylene oxide copolymer. Bone wax-filled defects remained unchanged at all time points with negligible healing observed. At 3 weeks, no evidence of alkylene oxide copolymer was observed at the application site, with fractional bone volume significantly greater than bone wax-treated defects (0.20 +/- 0.03 versus 0.02 +/- 0.01; P = 0.0003). At 6 and 12-weeks, alkylene oxide copolymer-treated defects continued to show significantly greater healing versus bone wax (0.18 +/- 0.04 versus 0.05 +/- 0.01 and 0.31 +/- 0.04 versus 0.06 +/- 0.02, respectively). At all time points, alkylene oxide copolymer-treated and control defects showed good healing with no significant difference.

CONCLUSION: Alkylene oxide copolymer is an effective hemostatic agent that does not inhibit osteogenesis or bone healing.