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4096092 
Journal Article 
Quinoline synthesis by improved Skraup-Doebner-Von Miller reactions utilizing acrolein diethyl acetal 
Ramann, GA; Cowen, BJ 
2015 
1 
Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581 
56 
46 
6436-6439 
English 
WOS:000364436300033 
A robust synthetic method has been developed as an improvement to the venerable Skraup-Doebner-Von Miller reaction providing access to various quinoline products. The straightforward procedure utilizes acrolein diethyl acetal as a three-carbon annulation partner with aniline substrates in a monophasic, organic solvent-free reaction medium. Differentially substituted aniline precursors were found to be compatible with the reaction conditions and the corresponding quinoline products are isolated in moderate to good yields. (C) 2015 Elsevier Ltd. All rights reserved. 
Heterocycle; Skraup-Doebner-Von Miller; Acetal