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HERO ID
4097235
Reference Type
Journal Article
Title
Multiple silk coatings on biphasic calcium phosphate scaffolds: effect on physical and mechanical properties and in vitro osteogenic response of human mesenchymal stem cells
Author(s)
Li, JJ; Gil, ES; Hayden, RS; Li, C; Roohani-Esfahani, SI; Kaplan, DL; Zreiqat, H
Year
2013
Is Peer Reviewed?
Yes
Journal
Biomacromolecules
ISSN:
1525-7797
Volume
14
Issue
7
Page Numbers
2179-2188
Language
English
PMID
23745709
DOI
10.1021/bm400303w
Abstract
Ceramic scaffolds such as biphasic calcium phosphate (BCP) have been widely studied and used for bone regeneration, but their brittleness and low mechanical strength are major drawbacks. We report the first systematic study on the effect of silk coating in improving the mechanical and biological properties of BCP scaffolds, including (1) optimization of the silk coating process by investigating multiple coatings, and (2) in vitro evaluation of the osteogenic response of human mesenchymal stem cells (hMSCs) on the coated scaffolds. Our results show that multiple silk coatings on BCP ceramic scaffolds can achieve a significant coating effect to approach the mechanical properties of native bone tissue and positively influence osteogenesis by hMSCs over an extended period. The silk coating method developed in this study represents a simple yet effective means of reinforcement that can be applied to other types of ceramic scaffolds with similar microstructure to improve osteogenic outcomes.
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