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4103362 
Journal Article 
MicroRNA-32 inhibits osteosarcoma cell proliferation and invasion by targeting Sox9 
Xu, JQ; Zhang, WB; Wan, R; Yang, YQ 
2014 
1 
Tumor Biology
ISSN: 1010-4283
EISSN: 1423-0380 
35 
10 
9847-9853 
English 
24989927 
WOS:000344532700049 
has retraction 4098513 Retraction Note to multiple articles in Tumor Biology
Increasing reports suggest that discovery of microRNAs (miRNAs) might provide a novel therapeutical target for human cancers, including osteosarcoma. Previous studies have shown that miR-32 was dysregulated in breast and endometrial cancer. However, its biological roles in osteosarcoma remain unclear. In the current study, we found that miR-32 was significantly down-regulated in osteosarcoma tissues, compared with the adjacent normal tissues. In vitro studies further demonstrated that miR-32 mimics were able to suppress, while its antisense oligos promoted cell proliferation in Saos-2 and U2OS cells. At the molecular level, our data further revealed that expression of Sox9 was negatively regulated by miR-32. Therefore, our results identify an important role for miR-32 in the osteosarcoma through regulating Sox9 expression.