Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4105395

Reference Type

Journal Article

Title

Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway

Author(s)

Li, J; Song, Z; Wang, Y; Yin, Y; Liu, Y; Yuan, R; Nan, X

Year

2016

Is Peer Reviewed?

Journal

Tumor Biology
ISSN: 1010-4283
EISSN: 1423-0380

Volume

Issue

Page Numbers

10587-10593

Language

English

PMID

26857281

DOI

10.1007/s13277-016-4954-9

Web of Science Id

WOS:000382672900059

Relationship(s)

has retraction 4098513 Retraction Note to multiple articles in Tumor Biology

Abstract

Sphingosine kinase 1 (SphK1) expression is elevated in various cancers and is associated with shorter survival times for patients. However, the molecular mechanism of SphK1 up-regulation in triple-negative breast cancer (TNBC) remains unclear. In this study, we assayed the expression level of SphK1 in TNBC tissues by qRT-PCR and immunohistochemistry. The level of S1P was quantified by ELISA in the serum of TNBC patients. Our results found that the levels of SphK1 and S1P were significantly increased in TNBC patients compared with normal control. Furthermore, knockdown of SphK1 with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion. These data suggest that SphK1 has an important role in TNBC and presents an attractive therapeutic target for the treatment for TNBC.