Health & Environmental Research Online (HERO)


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4106390 
Journal Article 
Transforming growth factor β receptor signaling restrains growth of pancreatic carcinoma cells 
Zhao, Z; Xi, H; Xu, D; Li, C 
2015 
1 
Tumor Biology
ISSN: 1010-4283
EISSN: 1423-0380 
36 
10 
7711-7716 
English 
25934336 
WOS:000362969900043 
has retraction 4098513 Retraction Note to multiple articles in Tumor Biology
Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant. Efficient control of cancer growth may substantially improve the survival of PDAC patients. However, no efficient treatments are so far available. Here, we inhibited transforming growth factor β (TGFβ) receptor signaling by overexpression of a key inhibitor of this pathway, SMAD7, in the mouse pancreas, using a recently developed intraductal infusion method. Overexpression of SMAD7 significantly increased growth of both implanted PDAC and PDAC by K-ras modification. Our data thus suggest that TGFβ receptor signaling restrains growth of PDAC, and modulation of TGFβ receptor signaling may be an effective treatment for PDAC.