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4107943 
Journal Article 
Point-of-care (POC) testing of lactate in the intensive care patient - Accuracy, reliability, and costs of different measurement systems (Retracted article. See vol. 55, pg. 903, 2011) 
Boldt, J; Kumle, B; Suttner, S; Haisch, G 
2001 
Yes 
Acta Anaesthesiologica Scandinavica
ISSN: 0001-5172
EISSN: 1399-6576 
45 
2 
194-199 
English 
11167165 
WOS:000166778100010 
has retraction 4104005 Retraction: Early recovery, cognitive function and costs of a desflurane inhalational vs. a total intravenous anaesthesia regimen in long-term surgery
Background: Point-of-care (POC) monitoring may facilitate diagnostic and therapeutic interventions in the critically ill. In a prospective study reliability and costs of two POC lactate testing devices were compared to the central laboratory lactate monitoring method.



Methods: From arterial whole blood and capillary blood samples of 40 intensive care unit (ICU) patients lactate concentrations were measured using either a battery-powered handheld lactate analyser (Accusport(R)) or a bench-top blood gas analyser (Chiron 865 series) and compared with lactate measured by the hospital's central laboratory ('reference' method). Measurements were carried out on the day of inclusion in the study ('baseline'), 8 h later, and in the morning of the 1st, 2nd, and 3rd days thereafter. Costs for blood lactate measurements were analysed for each method.



Results: A total of 197 lactate measurements were done with each system. Lactate measured from arterial blood using the Accusport(R) and the central laboratory showed excellent agreement (bias: -0.15 mmol/l; relative error: -2.74%). Lactate measured by the blood gas analyser had also excellent agreement with the reference method (bias: 0.09 mmol/l; relative error: 2.24%) and the hand-held device (bias: -0.24 mmol/l; relative error: -5.06%). Time from blood sampling to availability of data was significantly longer for the central laboratory (85+/-35 min [range: 45-168 min]) than for both POC systems (range: 1-10 [range: 45-168 min]) than for both POC systems (range: 1-10 min). Total cost for measuring blood lactate was lowest using the Accusport(R) device.



Conclusion: The trend towards miniaturizing laboratory monitoring devices will continue, resulting in greater flexibility of management of the critically ill. Blood lactate can rapidly, easily, accurately, and economically be measured at the bedside with the hand-held monitor apparatus Accusport(R) and the bench-top blood gas analyser. 
critically ill; point-of-care (POC); lactate; accuracy; costs; outcome; hypoperfusion