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4108288 
Journal Article 
Steroid receptor co-activator-3 promotes osteosarcoma progression through up-regulation of FoxM1 
Geng, S; Wang, X; Xu, X; Zhang, H; Ma, Y; Zhang, Y; Li, B; Bi, Z; Yang, C 
2014 
1 
Tumor Biology
ISSN: 1010-4283
EISSN: 1423-0380 
35 
4 
3087-3094 
English 
24282087 
WOS:000334495900031 
has retraction 4098513 Retraction Note to multiple articles in Tumor Biology
Increasing evidence suggests that the three homologous members of steroid receptor co-activator (SRC) family (SRC-1, SRC-2, and SRC-3) play key roles in enhancing cell proliferation in various human cancers, such as breast, prostate, and hepatocellular carcinoma. However, the function of SRC-3 in osteosarcoma remains largely unexplored. In the current study, we found that SRC-3, but not SRC-1 and SRC-2, was dramatically up-regulated in human osteosarcoma tissues, compared with adjacent normal tissues. To explore the functions of SRC-3 in osteosarcoma, in vitro studies were performed in MG63 and U2OS cells. SRC-3 overexpression promoted osteosarcoma cell proliferation, whereas knockdown of SRC-3 inhibits its proliferation. In support of these findings, we further demonstrated that SRC-3 up-regulated FoxM1 expression through co-activation of C/EBPγ. Together our results show that SRC-3 drives osteosarcoma progression and imply it as a therapeutic target to abrogate osteosarcoma.